What is Autoimmunity?

August 16, 2020 Ryan Vermeesch

If someone has an autoimmune disease, their immune system has essentially gone awry. The immune system ideally is on guard to protect the body and fight foreign invaders, such as bacteria and viruses. With an autoimmune disease, the body is not able to distinguish between its own cells and foreign cells, and it ends up attacking parts of its own body. This may involve an attack on a particular tissue in the body, an organ in the body, or even a group of organs in the case of a more systemic autoimmune condition.

Autoimmunity disproportionately affects women, though a recent study that looked for the prevalence of antinuclear antibodies (ANA- most common biomarker of autoimmunity) showed that autoimmunity rates for men may be on the rise in the United States. Other groups that showed ANA increases included non-Hispanic whites, adults 50 years or older, and adolescents- the most concerning group (1).

Scientists know about more than 80 autoimmune conditions (2). Some are more well known and acknowledged, while others are difficult to diagnose. With lesser known autoimmune conditions, patients may suffer years before getting a proper diagnosis. Some of the more well known autoimmune conditions include:

Immune Dysregulation

We know that an autoimmune condition involves the immune system becoming dysregulated. But what exactly is going on with the immune system?

This dysregulation involves an imbalance between effector T cells and regulatory T cells. Effector T cells are supposed to protect the body from pathogens by producing an immune response, while regulatory T cells suppress and calm the immune system.

Regulatory T cells maintain tolerance to self antigens, which are markers on just about every cell on the body. When the immune system identifies a foreign antigen, it will create antibodies against it.

In autoimmune conditions, effector T cells see antigens from necessary parts of the body (such as tissues or organs) as foreign and create autoantibodies against them. In autoimmune conditions, there are not enough regulatory T cells or not enough effective regulatory T cells to control this inappropriate immune response (3, 4). When working with autoimmune patients, building the regulatory T cell response is an important part of their recovery.

In autoimmune diseases, the body has chronic inflammation and an immune system that is always on alert. This consistent state of fight or flight can do significant damage to the body.

Stages of autoimmunity

There are three main stages of autoimmunity:

Silent Autoimmunity - The person has positive antibodies on lab tests but has no noticeable symptoms.
Autoimmune Reactivity - The person has positive antibodies on lab tests and has some “unexplainable” symptoms. This person may travel from doctor to doctor without getting any real answers or solutions.
Autoimmune Disease - The body has been damaged enough to have a diagnosis, and the person has many symptoms (5).

While we can support healing at any stage, early detection of an autoimmune condition, often provides a better outcome. It’s highly beneficial to lower your risk for developing an autoimmune disease by aiming to fill your plate with whole, nutrient-dense foods and by controlling environmental factors the best you can, such as limiting chemical exposure, finding ways to control stress, and getting adequate sleep.

Signs That You May Have an Autoimmune Condition

Family history of autoimmunity - It’s important to examine family history for the likelihood of developing autoimmunity. For example, if you have a parent or sibling who has Hashimoto’s, you are more likely to develop Hashimoto’s. If this is the case, it’s a good idea to focus on ways to improve and maintain health in proactive ways and have antibodies tested by a functional medicine practitioner.

Symptoms that wax and wane - In autoimmune conditions, you will oftentimes have significant flares in symptoms and then periods where symptoms seem to calm. This waxing and waning of symptoms is a classic sign of autoimmunity.

Stress/lack of sleep worsens your condition- If you notice that your symptoms seem to flare when you are stressed or are not getting adequate sleep, this is another sign that you may be battling an autoimmune condition.

Body pain/inflammation- You may have signs of inflammation, such as joint paint, muscle aches, redness/swelling, a recurring fever, and/or swollen glands.

Food sensitivities or intolerances- Signs of food intolerance include nausea, stomach pain, bloating, vomiting, heartburn, diarrhea, constipation, headaches, irritability, and/or nervousness. Food sensitivities or intolerances are potential indicators of an autoimmune condition.

Chronic illness- If your immune system is having trouble fighting off viruses and pathogens you are exposed to, that may be another sign to investigate whether or not you have an autoimmune condition.

While autoimmune disease rates have been skyrocketing over the last few decades, the gene pool has not changed very much. This leads us to believe that environmental factors, such as diet, toxin exposure, and stress may be to blame. While this can initially appear overwhelming, it is also empowering in that there are many factors that we can control to take back our health.

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